I'm currently running the following:
-ChuckPatch (1080pDocked+FSRDisable+QualityReduceFix+Shadow1024) - But I have them all separated lol
-Disable FXAA(non romfs) - Disables FXAA this is not the romfs version
-AnisotropicFix - The mod fixes possible black line artifacts when anisotropic filtering (AF) is enabled in Yuzu
-Serfrosts Defogger - A native attempt at reducing the game's oppressive fog to aid with visibility and color.
-Xbox UI Mod v9 - Normal - Colors - Adds the Xbox controller to the UI
-Buffed Archaic - A mod that increase the defense of the Archaic Clothes
In my opinion, it would be convenient to have one just in case there's an emergency (hopefully not) and you hypothetically would need to drive to resolve that emergency. I would personally get it even if I'm not planning on driving any time in the future, just in case.