These are all great answers. As discussed in another answer to a comment (the one on Poison Ivy and Mr Freeze), I agree that "believable" experiments gone wrong based on actual science provide a source of "believable" super powers.
On the other hand: Ghost Rider and Spawn have really nice origin stories which also place restrictions on what they can do not to make the characters god like.
I'm trying to answer everyone and you pointed out correctly something I didn't define well in my original post: I was trying to find either "believable" powers (in the sense of being well constructed) or "believable" origin stories. They didn't need to come from radioactivity only. The reason I was excluding mutants in my original post was that they have powers since they have a different gene, but that is a very "cheap" way of creating a superhero, since no other explanation is necessary!
Wolverine (as pointed out in the first answer to your comment) is born a mutant and later on given an indestructible skeleton.
Make no mistake: the post is not about superheroes being or not being cool because of their origin story or super powers. I really like Wolverine and Sabertooth!