I am nearsighted and wear glasses all the time. I don't have any issues wearing them inside the PSVR2, but mine are small profile. Someone did a good write-up on Reddit of third party snap-in prescription lenses that you can get: https://www.reddit.com/r/PSVR/comments/13t98jk/psvr_2_lens_insert_comparison_vr_optician_hons_vr/
My understanding is that you can play any game that is not VR compatible in cinema mode, but I have not done so.