I started off with Ubuntu Studio when I first switched to Linux from Macs,.. I dunno how long ago. Then I switched to regular Ubuntu with XFCE since I didn't use half of what Ubuntu Studio came with and when Canonincal announced their IPO plans, figured I'd use it as an excuse to explore Debian so pretty much I just use Debian nowadays.
I tend to use SuperCollider (sometimes with TidalCycles running for live coding), Pure Data, Audacity, and very rarely a DAW (but if I do, Ardour). I use an RME Fireface UCX which is USB class-compliant I think it's called(?). I dunno, I used go the normal JACK route with qjackctl but switched over the Pipewire (which I finally got down to usable latencies while playing a bass going through the interface without too many xruns) and qpwgraph for routing. I dunno, it just works more-or-less and isn't so much trouble to set up (was a bit more painful with the normal JACK route and feeding PulseAudio into JACK and doing all the PulseAudio/JACK sink stuff, Pipewire has made that workflow significantly more streamlined).