Fedora Linux: It's your Operating System.

Fedora works just fine with two screens. You'd choose a primary screen, and you can choose the placement so the mouse will travel between screens with ease. I ran it for years like that. Let us know if you have any specific questions about the way something would work.

I’ve used fedora with gnome on two screens for over a decade. There’s no issues at all.

I prefer to change the setting of “workspaces on primary display only” to off. Workspaces are then across both displays and change together unlike the default behavior which is similar to Mac OS where spaces only work on the primary display.

I can also confirm that dual and triple display setups work in Fedora with Gnome.

You can choose whether workspaces apply to both screens or just a primary screen (so if, for example, you want the smaller screen to be static while you multi-task you can).

My setup is a ThinkPad attached to a larger external monitor, mainly I use the one screen but occasionally I'll use the ThinkPad screen as a second screen - all works seamlessly and you can configure it how you like.