Danger Dust

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A community for those occupationally exposed to dusts, toxins, pollutants, hazardous materials or noxious environments

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Bampot

De novo designed proteins neutralize lethal snake venom toxins | Nature (www.nature.com)

submitted 2 days ago by Bampot to c/dangerdust

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With limited experimental screening, we obtained protein designs with remarkable thermal stability, high binding affinity and near-atomic-level agreement with the computational models. The designed proteins effectively neutralized all three 3FTx subfamilies in vitro and protected mice from a lethal neurotoxin challenge. Such potent, stable and readily manufacturable toxin-neutralizing proteins could provide the basis for safer, cost-effective and widely accessible next-generation antivenom therapeutics.

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