We have decent luck with tomatoes, appart from the slugs and groundhogs eating some of the fruit. Our main challenges thus far have been keeping up with pruning and trellising to help minimize the slugs and powdery mildew.
We are growing both determinate and indeterminate tomatoes this year and we will try the Florida weave with t-posts for the indeterminate, and regular basket cages for the determinates.
We feed the tomatoes with kelp or alphalfa meal and keep them mulched with straw which really helps with keeping them lush and hydrated, respectively. This year we hope to add more of our own compost as our compost pile grows. We also started some fermented greens to water with.
I'd be interested in hearing from others about what works for them! It the secret to just suck it up and be really ruthless with pruning?