microdosing.

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Welcome to our community focused on microdosing psychedelics! Here, we offer support, valuable information, shared experiences, and discussions on health related to this practice. Everyone is encouraged to join and contribute by sharing their personal experiences and insights.

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Anyone has experience with micro- or macrodosing while on atypical/second-generation antipsychotics? (self.microdosing)

submitted 8 months ago by ickplant to c/microdosing

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I'm going to ask my psychiatrist before making decisions about dosing, but I am looking for personal experiences.

Reason for asking: In the Microdosing Handbook, the author says that atypical antipsychotics should theoretically render mushrooms ineffective because they block the 5-HT2A serotonin receptors that psilocin acts upon.

I'm on Vraylar. However, when I took 0.5 grams of shrooms, I definitely felt some mild sensory and cognitive effects.

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[–] ShunkW 4 points 8 months ago (1 children)

I've been on abilify and 2 grams of shrooms had zero effect.

[–] ickplant 2 points 8 months ago (1 children)

So interesting, thank you for sharing. I wonder if you experienced any non-psychedelic effects, like improved mood or reduced anxiety?

[–] ShunkW 2 points 8 months ago (2 children)

I didn't notice any particular effects that I would attribute to the shrooms honestly. I honestly had a mood downturn because I was frustrated and pissed off that they had no effect even though I had stopped taking the abilify like 3 days beforehand

[–] ickplant 1 points 8 months ago

Got it, thank you so much for sharing your experience.

[–] ickplant 1 points 8 months ago

Got it, thank you so much for sharing your experience.