I've been running on Arch for the past few years and using PipeWire with the relevant drop in packages for the last year or so to handle audio. Wouldn't necessarily recommend Arch for someone mainly focused on doing production work as brand new PipeWire releases sometimes cause issues.
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Ardour for working on music / audio editing
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qpwgraph for routing (i used to use qjackctl but qpwgraph is built with PipeWire in mind and does what i need + can save and load routing )
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carla-rack for mic processing (some noise reduction, compressor, eq for voice chat / OBS recording fed into a virtual mic source)
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the
pro-audio
package group on Arch provides a bunch of tools and plugins conveniently. I just keep all of them installed and find something new to try out here and there. You can see what packages are part of that group for inspiration and find the packages for whatever distro you wanna use -
i make the most use of x42, LSP, and Calf plugins for day to day stuff
Other than that just some bash scripts that run pactl
commands to create the virtual sinks and sources I typically use on startup, then when qpwgraph is started it will load my saved routing to those sources