this post was submitted on 08 Jul 2023
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[–] null_ 108 points 1 year ago* (last edited 1 year ago) (6 children)

There is a lot of public misunderstanding of the rodent studies that linked aspartame to cancer, which are very flawed and essentially come from a single Italian research group.

There is still no definitive link to cancer risk in humans so I would continue to be skeptical. The maximum recommended safe exposure for aspartame is the equivalent of 12 cans of coke, and the strong effects from the rodent study were using exposure amounts equivalent to 5 times that amount, or 60 cans daily, every day of their life after day 12 of fetal life (i.e. before birth).

Almost anything can cause long-term health risks and toxicity at such massive exposure levels.

https://www.cancer.org/cancer/risk-prevention/chemicals/aspartame.html

Link to the free Pubmed link to one of the original source studies from 2008 so you can see their methodology and the absurdly massive exposure amounts needed to ovserve these effects:

https://pubmed.ncbi.nlm.nih.gov/17805418/

[–] [email protected] 28 points 1 year ago* (last edited 1 year ago) (2 children)

I disagree with the 'massive' exposure 'needed' to observe these effects exaggeration. First, the point of the study was to show it can be carcinogenic, not to parse at exactly what level in humans. Second, effects are seen at the 400ppm level which equates to 20mg/kg. This is 1600mg/day or 8 cans of Diet Coke (@200mg/can) for an 80kg male. That is NOT an impossible level of daily consumption for many.

I suspect further research was done to confirm your linked studies and refine exactly at what minimum levels of daily consumption elicit carcinogenic effects. That will likely be in the full report once released. Until then, you sound like you don't want it to be true, rather than an impartial evaluator of the research.

[–] [email protected] 4 points 1 year ago (1 children)

Apple seeds can kill you in large enough quantities

[–] MaxVoltage -2 points 1 year ago

Found the cigarette smoker

[–] [email protected] -3 points 1 year ago* (last edited 1 year ago) (3 children)

the point of the study was to show it can be carcinogenic

Almost anything can be carcinogenic with a high enough exposure. You can pump a rat full of water until it dies and declare that water kills people. But, that doesn't prove anything or serve a point.

Second, effects are seen at the 400ppm level which equates to 20mg/kg. This is 1600mg/day or 8 cans of Diet Coke (@200mg/can) for an 80kg male. That is NOT an impossible level of daily consumption for many.

In rats! You can't just multiple a rat study by body weight and expect it to always correlate. That's why studies are done in larger animals, and sometimes the concept just dies there.

A single study is a statistic. Until they duplicate the results multiple times, and upgrade to monkeys, pigs, or (in a safe way) humans, this is all just noise.

[–] [email protected] 14 points 1 year ago

Almost anything can be carcinogenic with a high enough exposure. You can pump a rat full of water until it dies and declare that water kills people.

It would lead to death, but not to cancer. Not everything is carcinogenic, even with high exposure. Causing death by a method other than cancer doesn't make it carcinogenic.

[–] [email protected] 11 points 1 year ago* (last edited 1 year ago) (1 children)

Almost anything can be carcinogenic with a high enough exposure. You can pump a rat full of water until it dies and declare that water kills people. But, that doesn’t prove anything or serve a point.

This is how science is done friend. You make no assumptions. You have reason to believe a theory predicts a testable outcome? You test it. Not everything causes cancer. Pure air doesn't... Clean water doesn't... The research shows us Aspartame does indeed have carcinogenic effects in rats. Now we know this, and the result can be used to support applications for more costly research using subjects much more similar to our anatomy because if it is carcinogenic in one mammal, it probably is carcinogenic in others.

You call the study flawed when it looks perfectly fine to me for the purpose it was designed for. It shows it is carcinogenic in the mammal it was tested on at dosage levels that translate to non-'massive', quite reasonable consumption rates for humans. As such, it warrants concern and all these claims by the European and US Food Agencies saying 'we did 100s of studies decades ago and it is fine trust me bro' is not enough. I'm not arguing this one study proves Aspartame causes cancer in humans. I'm saying your particular criticisms of it are unfounded as is your confidence that Aspartame is non-carcinogenic. You cite FDA claims 'Aspartame is safe' but show no research that supports this conclusion. Looking at the provided links I noticed things like "don't feed to pregnant mothers because phenylalanine", "methanol is a metabolite - nothing concerning there", and 'we plan on doing a systemic revaluation of aspartame as the research is over a decade old (the whole time with the biggest corporations in the world breathing down our necks)' https://www.efsa.europa.eu/sites/default/files/corporate_publications/files/factsheetaspartame.pdf

Looks to me like somebody did more research and found contradictory results otherwise why would WHO say they are going to do this?

[–] [email protected] -1 points 1 year ago

You cite FDA claims ‘Aspartame is safe’ but show no research that supports this conclusion. Looking at the provided links I noticed things like “don’t feed to pregnant mothers because phenylalanine”, “methanol is a metabolite - nothing concerning there”, and ‘we plan on doing a systemic revaluation of aspartame as the research is over a decade old (the whole time with the biggest corporations in the world breathing down our necks)’ https://www.efsa.europa.eu/sites/default/files/corporate_publications/files/factsheetaspartame.pdf

I do? Which post do I claim anything? What links did I provide?

My whole point is that one flawed study with rats doesn't prove a damn thing, and is not enough to make a decision on.

[–] [email protected] 10 points 1 year ago

I'm going to agree with Burstar here - if you're setting out to prove that something is possible, you're going to give it the best chance you can. Once you know its possible (whether its something like using an arduino to simulate an old price of hardware, or if a compound can cause cancer), you go and refine it down.

[–] [email protected] 25 points 1 year ago (1 children)

the strong effects from the rodent study were using exposure amounts equivalent to 5 times that amount, or 60 cans daily, every day of their life after day 12 of fetal life (i.e. before birth).

This is why I hate rodent studies. They always up the exposure to whatever they are testing to hyper-extreme limits. Then point their flawed results to the world and declare "See! X causes Y!"

There are even similar rat studies for marijuana that try to link it to cancer as well, despite the fact that zero people have actually died from weed. It's all overblown bullshit.

[–] [email protected] 22 points 1 year ago (1 children)

Also note most people are choosing between sugar and aspartame or another sweetener, and sugar is pretty much categorically a health risk for humans.

[–] BarrelAgedBoredom 11 points 1 year ago

Nail on the head. Aspartame is still better for you than super processed foods loaded with sugar. This reminds me of the big smear campaign against fat that the sugar industry engineered to take the heat off of themselves way back when

[–] [email protected] 4 points 1 year ago

Is that a measurement relative to mass/size? Because if not, you'd need to consume a shitload of it to really do anything.

There's a ton of studies with these problems. Researchers simply engrossing the test subject in the material until something bad happens. Unless you're researching on a test group of humans, then suddenly all the levels are actually less than typical.

It all depends if you're looking to prove that it's harmful or not. Want to find it's harmful? Get a bunch of mice and expose them to as much of whatever substance you need to in order to find a problem.... Want to prove something is safe, set up a "double blind" study of the effects on humans, and give half of them regulated and limited doses of it for weeks or months until you can convince everyone that "nothing bad happened".

I have a problem with research done in either way. Researchers should be neutral, and just test and let the data speak for itself. (With limited interpretation for the people who read it)

Instead, almost all research is funded by someone with an agenda who is trying to find out if x is good/bad, and prove or disprove a specific stance. Argh

[–] [email protected] 1 points 1 year ago (1 children)

Still proves it may cause cancer, the only thing seriously in question is the dose. Seemingly nobody knows what a safe upper bound is for any population.

[–] [email protected] 1 points 1 year ago

At some point you gotta stop believing some theories and listen to the science.

[–] [email protected] -3 points 1 year ago

Hello Cocacola CEO