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Supergirl Found: Milly Alcock to Play Heroine in James Gunn’s DC Movies
(www.hollywoodreporter.com)
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She went from relatively small roles to starring in an HBO TV show (albeit for less than one season) to a lead role in a comic book film franchise. That's a huge leap.
As long as the film is just OK she'll do fine and set herself up for plenty more work. Look at Daisy Ridley, Star Wars is obviously a bigger franchise and the films with her were poorly received (generally) but everyone recognizes it wasn't her fault and now she's got plenty of films lined up.
Also look at the terrible Sony Marvel films, Tom Hardy did two (soon three) of those, Jared Leto & Matt Smith did Morbius, Aaron Taylor-Johnson & Russell Crowe have Kraken coming out. Those are sizable actors doing terrible films, I'm confident they got paid. (Also Dakota Johnson & Sydney Sweeney will be in Madame Web, smaller actors but money for sure.)
In general taking the big franchise is a safe bet. It used to be safer in MCU land, but still safe. DC you have to hope, but at least Gunn has a good track record so far.