Currently I'm doing a pure vanilla run to officially get all of the achievements I missed in previous games (Lazy Bastard, The 3rd tier circuit ones, Minions, and even Watch Your Step).

It took me an embarrassing 15:15:00 to launch a rocket with default ores and no pollution spreading, even though I'd previously done a vanilla run in under 7 hours. My current base has much more spaghetti than that one. Now I gotta scale up to get the rest of the achievements.

After that, I'll either go back to my vanilla megabase attempt (272h), my Bob's/Angel's base to get all the SpaceX stuff (currently launched 1 rocket at 123h), or start a K2 run.