One monitor is vertical for reading documents, the other horizontal. Dell monitors one is a p2422h, the other u2722d. It would be nice to have windows that span both monitors occasionally, but they get so misaligned as to make this untenable. Is there any easy way to get resolution settings and alignment in this configuration to allow distortionless spanning windows or am I just entering a world of hurt trying to do this?
The problem is that those two monitors have slightly different DPI - the 24 has roughly 93 DPI while the 27 has around 109. Even if you align them in the multi monitor setting page, they'll be aligned only at a certain point. You can probably play around with the scaling settings (you'll need to set something like 15% difference between the two).