this post was submitted on 16 Jun 2023
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Curious about the cocaine comment. Does it interact with the drug that will make you sick or just a bad time mentally?
You do know anxiety itself carries a heart attack risk, right? A person without anxiety taking propanolol might increase the risk, but for someone with crippling anxiety I'd wager it might be a net benefit.
I was referring to mixing cocaine with propranolol
edit: I think something broke lol
It looks like I somehow replied to every reply to the original comment and now I look like a jackass
oopsie
Propanolol (and other beta blockers) ... blocks a type of` receptor found on cells call beta adrenergic receptors. In the heart, beta blockers work to help with rate control.
Cocaine activates beta and alpha adrenergic receptors. Activating alpha adrenergic receptors can cause vasoconstriction.
Combining them, you get unopposed alpha activity, leading to coronary artery constriction, and a significant increase in risk of heart attack.
edited to change "ion channel" to "receptor"