this post was submitted on 02 Feb 2025
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There are both DNA and RNA viruses. Not all viruses incorporate themselves into the host genome, thus the special term ‘retroviruses’ for those that do.
Woah, I've only ever seen 'retrovirus' in reference to things like "scientists find retrovirus in ice!" So I totally thought it meant retro virus. I was wrong lol
HIV is the most famous retrovirus. The reason it's hard to cure is basically once it goes from bloodstream to the host cells, it adds itself to the host DNA and RNA, then it just replicates with our cells and that our cell will produce more of it.
Truly ‘retro’ viruses are too cool to use the term! It’s such an annoying hipster vibe they give off
A retrovirus does transcription in the opposite direction. It's RNA genome is used as a template to create DNA which is then used to hijack the host cell and replicate the virus. It's a bit like a cuckoo bird laying it's egg in the host nest, only once that egg hatches it turns the other eggs into cuckoos as well.
Retroviruses were entirely theoretical prior to HIV, as RNA is famous for being unstable. Anyone who has worked in a genetics lab can tell you how big a PITA RNA can be, as even a heavy bump to the lab bench can ruin an experiment.