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The Sistine Chapel ceiling - Michelangelo di Lodovico Buonarroti Simoni (1508 - 1512)
(upload.wikimedia.org)
The Sistine Chapel ceiling (Italian: Soffitto della Cappella Sistina), painted in fresco by Michelangelo between 1508 and 1512, is a cornerstone work of High Renaissance art.
The Sistine Chapel is the large papal chapel built within the Vatican between 1477 and 1480 by Pope Sixtus IV, for whom the chapel is named. The ceiling was painted at the commission of Pope Julius II.
My favorite part is the snake with the skin like a human, in the garden of Eden. That always freaked me out as a kid.