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FFmpeg devs boast of up to 94x performance boost after implementing handwritten AVX-512 assembly code
(www.tomshardware.com)
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The point isn't that it's handwritten code, it's handwritten assembly. All code is written by hand to some degree, but it's normally in a higher-level language and compiles down to machine code. Assembly is basically as close as you can get to the bare hardware in terms of control.