Memes

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A meme is an idea, behavior, or style that spreads by means of imitation from person to person within a culture and often carries symbolic meaning representing a particular phenomenon or theme.

An Internet meme or meme, is a cultural item that is spread via the Internet, often through social media platforms. The name is by the concept of memes proposed by Richard Dawkins in 1972. Internet memes can take various forms, such as images, videos, GIFs, and various other viral sensations.

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Laittakaa meemejä tänne.

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There can be only one winner (lemmy.world)

submitted 3 months ago by The_Picard_Maneuver to c/[email protected]

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[–] [email protected] 8 points 3 months ago* (last edited 2 months ago) (1 children)

So caffeine binds to adenosine receptors to block adenosine's drowsiness effect. Melatonin binds to melatonin receptors to regulate circadian rhythms. As far as how adenosine interacts with melatonin, no idea. I'm no biochemist and what I'm about to say could be 100% incorrect, but it seems that adenosine is involved in melatonin production?

So if it's true that adenosine leads to melatonin production, then I'm guessing that the adenosine-blocking effect of caffeine would be (partially?) negated by ingesting a melatonin supplement, especially in the massive doses that they sell.

~~My money is on SLEEP.~~ [I got it backwards!! See below replies.]

[–] Drewsteau 4 points 3 months ago* (last edited 3 months ago) (1 children)

You’re on the right track, but funnily enough you got it switched around!

Research shows that melatonin binding leads to downstream release of adenosine, so if caffeine is blocking its binding action sleep is not on the way!

Here’s the paper I am referencing: https://doi.org/10.1016%2Fj.neuron.2015.02.016

“We find that melatonin promotes sleep downstream of the circadian clock as it is not required to initiate or maintain circadian rhythms. Additionally, we provide evidence that melatonin may induce sleep in part by promoting adenosine signaling, thus potentially linking circadian and homeostatic control of sleep”

[–] [email protected] 3 points 2 months ago

Ohh so melatonin leads to adenosine production, which caffeine blocks. so NO SLEEP is the smart bet. that makes a lot of sense, yeah! and when you think about it, coffee at night is gonna make for poor sleep no matter how much melatonin you take.