For me it's Corner Gas. I still think it's pretty funny and there's a decent amount of references to Canadian stuff but not enough to be off-putting. I feel like an American wouldn't be confused watching it even if some of the references get a bit dated overtime.
I have only seen a bit of the animated version in waiting rooms.
Le maître du jeu (aka Taskmaster Canada), if game shows count.
I know it's Quebecois and not really full Canadian, but it's awesome. English subtitles are also available.