Philippines

if I understood it correctly, the transmission of rabies from bite site to the brain is not completely understood

you just said it step by step, but to add more details rabies spreads through circulation and population, to answer the question do rabies only targets neurons hard no, so before it reaches the head it does it things, replicate and destroy its targets, and that will trigger an immune response kung wala man symptoms of rabies the infected cells will probably release pyrogens and inflammatory cytokines at dito na mapapansin ng victim na merong something mali sa kanya at pag nagpa doctor siya maaaring ma-advisan siya na baka nga dahil sa rabies, those subject to research probably lie or lacking self-awareness that something is wrong with their body since rabies virus if outside the cell will be detected by complement proteins and if inside of infected cell will be detected by KTC and NKC, maiintindihan ko pa kung bacteria eh since bacteria have a mechanism called quorum sensing which is their way to hide when in danger cause by antibiotics or immune response

Nagpa-antirabies ako 2 years ago. Sabi nung doktor, effective daw yung shot up to 2 years. Pero kung nakagat sa collarbone pataas, kailangan magpa-injection ulit.

I've questions for you, does the further to brain the higher the survivability? I have a guess yes since the immune response will prevail over rabies virus, it's not as smart as Kurzgesagt portrays it to be rabies virus action is actually frankly messy, I've also watched Kurzgesagt video on rabies it said that neurons can shut down an immune cell but ChatGPT said otherwise here's the list of cell from our body that can shutdown an immune cell based on ChatGPT (Cytotoxic T cells, Natural Killer (NK) cells, Macrophages, Regulatory T cells (Tregs), Dendritic cells (DCs), B cells, Endothelial cells.

Here's what I asked ChatGPT on Kurzgesagt claims that a neuron can shutdown an immune cell:

prompt: can rabies virus control a neuron to shutdown an immune cell

response: No, the rabies virus cannot directly control a neuron to shut down an immune cell. Rabies primarily affects neurons within the central nervous system, leading to neurological symptoms and ultimately death. While the virus can indirectly impact the immune system through its effects on the nervous system, it does not have direct control over immune cells. During a rabies infection, the virus primarily targets neurons and spreads within the nervous system. The virus hijacks the cellular machinery of neurons to replicate itself and spread further. As the infection progresses, the immune system responds by mounting an immune response to eliminate the virus. The immune response against the rabies virus involves the activation of immune cells, such as T cells, B cells, and macrophages, to recognize and eliminate the virus. The immune cells interact with infected neurons, attempting to clear the virus and control the infection. However, the rabies virus has developed mechanisms to evade and interfere with the immune response. It can manipulate certain host proteins and interfere with the production of antiviral molecules, dampening the immune response and allowing the virus to persist within neurons. While the immune response can play a role in clearing the infection, the ability of the rabies virus to evade and interfere with immune cells can contribute to the progression of the disease and its evasion of immune defenses. Therefore, while the rabies virus can affect immune responses indirectly through its impact on neurons and the nervous system, it does not have direct control over immune cells to shut them down. The complex interactions between the virus, neurons, and the immune system contribute to the pathogenesis of rabies.

viral load doesn't matter since viruses are able to replicate faster