Danger Dust

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A community for those occupationally exposed to dusts, toxins, pollutants, hazardous materials or noxious environments

Dangerous Dusts , Fibres, Toxins, Pollutants, Occupational Hazards, Stonemasonry, Construction News and Environmental Issues

#Occupational Diseases

#Autoimmune Diseases

#Silicosis

#Cancer

#COPD

#Chronic Fatigue

#Hazardous Materials

#Kidney Disease

#Pneumoconiosis

#The Environment

#Pollutants

#Pesticides

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Bampot

Centrality of Myeloid-Lineage Phagocytes in Particle-Triggered Inflammation and Autoimmunity (www.ncbi.nlm.nih.gov)

submitted 3 months ago by Bampot to c/dangerdust

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A prototypical example is occupational exposure to respirable crystalline silica, which is etiologically linked to systemic lupus erythematosus (SLE) and other human autoimmune diseases. Silica-induced immunogenic cell death and danger signal release triggers accumulation of T and B cells, along with IgG-secreting plasma cells, indicative of ectopic lymphoid tissue neogenesis, and broad-spectrum autoantibody production in the lung. These events drive early autoimmunity onset and accelerate end-stage autoimmune glomerulonephritis.

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