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Discussion about the psychedelic experience more specifically at https://lemmy.world/c/psychedelic
Isnt DMT literaly the drug released in the brain during a near death experience? Seems odd that Ketamine is closer 🤷
“After assessing the semantic similarity between 15,000 reports linked to the use of 165 psychoactive substances with 625 NDE {Near Death Experience} narratives, we determined that the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine consistently resulted in reports most similar to those associated with NDEs. Ketamine was followed by Salvia divinorum and a series of serotonergic psychedelics, including the endogenous serotonin 2A receptor agonist N,N-Dimethyltryptamine (DMT). This similarity was driven by semantic concepts related to consciousness of the self and the environment, but also by those associated with the therapeutic, ceremonial and religious aspects of drug use. Our analysis sheds light on the long-standing link between certain drugs and the experience of “dying“, suggests that ketamine could be used as a safe and reversible experimental model for NDE phenomenology, and supports the speculation that endogenous NMDA antagonists with neuroprotective properties may be released in the proximity of death.” (Neurochemical models of near-death experiences: A large-scale study based on the semantic similarity of written reports, Martial, et al, 2019).
Here ketamine, like DMT, is hypothesized to act on similar receptors to form similar brainwaves, with similar subjective experiences related to proximity to death.
More here— https://psychedelic-institute-of-mental-health.ghost.io/does-the-psychedelic-experience-matter/
Yeahhhh I was gonna say this definitely seems off. I have plenty of experience with LSD/psilocybin/DMT/mescaline and to put DMT below the others, especially shrooms, tells me that they have no idea what they're talking about. I think salvia is definitely in the right spot though, and although I've never tried it, 5-meo-dmt is supposed to be even more intense than DMT so it should be much much higher.
Also, the active ingredients in Ayahuasca are DMT and 5-meo-dmt, but you take a maoi to make them last much longer. Putting Ayahuasca that far below DMT is kind of ridiculous.
Also also, 5-aco-dmt is a prodrug for psilocybin. Your body turns it into it. They are technically the same thing, so why the huge disparity there?
Also also also (I just noticed peyote cactus, Peruvian torch cactus, and mescaline are all separate entries), the active ingredient in peyote and Peruvian torch is mescaline. They are one and the same. Wtf lol....