Now that Marvel got them, I doubt its gonna be any reboots after the next, in quite a while.
But they will have to switch out actors as they move on to new projects, becomes too expensive, or get too old for the role. And leaving their biggest earning superheroes unused or dead isnt profitable. I'm calling it: Iron Man and Captain America will return, played by new actors, still within the same MCU continuity, within a decade.