The present paper critically reviews the models of PAT framing to provide a comprehensive picture of current practices in clinical psychedelic research. While some structural aspects of PAT seem to recur in clinical studies, the therapeutic stance and theoretical frameworks seem far from being exhaustively defined. Considering that psychedelics seem to enhance sensitivity to the internal and external environment (i.e., suggestibility), future research should provide more details on how such environments are constructed in terms of suggestions, description of the mechanisms underlying conditions and treatments, setting of expectations, therapeutic models employed and quality of the therapeutic relationship. This review fills a gap in the current literature and provides a systematic way to think about psychotherapeutic framing of PAT. The concepts discussed above are relevant to future construction of studies, designing of training programs for aspiring psychedelic psychotherapists and are presented with the intention to contribute to the development and implementation of PAT in several fields of psychiatric, psychological and medical relevance.